Guadalajarences?

For reasons that are not entirely clear, very few people from cities in Latin American have demonyms which have obvious origins.

People from Mexico City are chilangos.

From Buenos Aires, portenos. 

Bogota, rolos. 

And people from Guadalajara are called tapatios. 

The term apparently derives from an old Nahuatl coin or monetary unit, the tapatiotl. 

It is also a brand of hot sauce.